RHYTHM-AF: design of an international registry on cardioversion of atrial fibrillation and characteristics of participating centers
Identifieur interne : 005277 ( Main/Exploration ); précédent : 005276; suivant : 005278RHYTHM-AF: design of an international registry on cardioversion of atrial fibrillation and characteristics of participating centers
Auteurs : Harry Jgm Crijns [Pays-Bas] ; Lori D. Bash [États-Unis] ; François Chazelle [France] ; Jean-Yves Le Heuzey [France] ; Thorsten Lewalter [Allemagne] ; Gregory Yh Lip [Royaume-Uni] ; Aldo P. Maggioni [Italie] ; Alfonso Martín [Espagne] ; Piotr Ponikowski [Pologne] ; M Rten Rosenqvist [Suède] ; Prashanthan Sanders [Australie] ; Mauricio Scanavacca [Brésil] ; Alexandra A. Bernhardt [Allemagne] ; Sreevalsa Unniachan [États-Unis] ; Hemant M. Phatak [États-Unis] ; Anselm K. Gitt [Allemagne]Source :
- BMC Cardiovascular Disorders [ 1471-2261 ] ; 2012.
Abstract
Atrial fibrillation is a serious public health problem posing a considerable burden to not only patients, but the healthcare environment due to high rates of morbidity, mortality, and medical resource utilization. There are limited data on the variation in treatment practice patterns across different countries, healthcare settings and the associated health outcomes.
RHYTHM-AF was a prospective observational multinational study of management of recent onset atrial fibrillation patients considered for cardioversion designed to collect data on international treatment patterns and short term outcomes related to cardioversion. We present data collected in 10 countries between May 2010 and June 2011. Enrollment was ongoing in Italy and Brazil at the time of data analysis. Data were collected at the time of atrial fibrillation episode in all countries (Australia, Brazil, France, Germany, Italy, Netherlands, Poland, Spain, Sweden, United Kingdom), and cumulative follow-up data were collected at day 60 (±10) in all but Spain. Information on center characteristics, enrollment data, patient demographics, detail of atrial fibrillation episode, medical history, diagnostic procedures, acute treatment of atrial fibrillation, discharge information and the follow-up data on major events and rehospitalizations up to day 60 were collected.
A total of 3940 patients were enrolled from 175 acute care centers. 70.5% of the centers were either academic (44%) or teaching (26%) hospitals with an overall median capacity of 510 beds. The sites were mostly specialized with anticoagulation clinics (65.9%), heart failure (75.1%) and hypertension clinics (60.1%) available. The RHYTHM-AF registry will provide insight into regional variability of antiarrhythmic and antithrombotic treatment of atrial fibrillation, the appropriateness of such treatments with respect to outcomes, and their cost-efficacy. Observations will help inform strategies to improve cardiovascular outcomes in patients with atrial fibrillation.
Clinical trials NCT01119716
Url:
DOI: 10.1186/1471-2261-12-85
PubMed: 23031215
PubMed Central: 3507765
Affiliations:
- Allemagne, Australie, Brésil, Espagne, France, Italie, Pays-Bas, Pologne, Royaume-Uni, Suède, États-Unis
- Angleterre, Communauté de Madrid, District de Cologne, Midlands de l'Ouest, New Jersey, Rhénanie-du-Nord-Westphalie, Svealand, État de São Paulo, Île-de-France
- Birmingham, Bonn, Madrid, Paris, Stockholm, São Paulo
- Université de Birmingham, Université de São Paulo
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Bash</name><affiliation wicri:level="2"><nlm:aff id="I2">Merck & Co., Inc, Whitehouse Station, Readington, NJ, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merck & Co., Inc, Whitehouse Station, Readington, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Chazelle, Francois" sort="Chazelle, Francois" uniqKey="Chazelle F" first="François" last="Chazelle">François Chazelle</name><affiliation wicri:level="3"><nlm:aff id="I3">Merck, Sharpe & Dohme, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Merck, Sharpe & Dohme, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Le Heuzey, Jean Yves" sort="Le Heuzey, Jean Yves" uniqKey="Le Heuzey J" first="Jean-Yves" last="Le Heuzey">Jean-Yves Le Heuzey</name><affiliation wicri:level="3"><nlm:aff id="I4">European Hospital Georges Pompidou, Rene Descartes University, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>European Hospital Georges Pompidou, Rene Descartes University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lewalter, Thorsten" sort="Lewalter, Thorsten" uniqKey="Lewalter T" first="Thorsten" last="Lewalter">Thorsten Lewalter</name><affiliation wicri:level="3"><nlm:aff id="I5">University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Lip, Gregory Yh" sort="Lip, Gregory Yh" uniqKey="Lip G" first="Gregory Yh" last="Lip">Gregory Yh Lip</name><affiliation wicri:level="4"><nlm:aff id="I6">University of Birmingham, Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region><settlement type="city">Birmingham</settlement></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Maggioni, Aldo P" sort="Maggioni, Aldo P" uniqKey="Maggioni A" first="Aldo P" last="Maggioni">Aldo P. Maggioni</name><affiliation wicri:level="1"><nlm:aff id="I7">ANMCO Research Center, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>ANMCO Research Center, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Alfonso" sort="Martin, Alfonso" uniqKey="Martin A" first="Alfonso" last="Martín">Alfonso Martín</name><affiliation wicri:level="3"><nlm:aff id="I8">University Hospital Severo Ochoa, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>University Hospital Severo Ochoa, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Ponikowski, Piotr" sort="Ponikowski, Piotr" uniqKey="Ponikowski P" first="Piotr" last="Ponikowski">Piotr Ponikowski</name><affiliation wicri:level="1"><nlm:aff id="I9">Medical University, Wroclaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Medical University, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Rosenqvist, M Rten" sort="Rosenqvist, M Rten" uniqKey="Rosenqvist M" first="M Rten" last="Rosenqvist">M Rten Rosenqvist</name><affiliation wicri:level="3"><nlm:aff id="I10">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Sanders, Prashanthan" sort="Sanders, Prashanthan" uniqKey="Sanders P" first="Prashanthan" last="Sanders">Prashanthan Sanders</name><affiliation wicri:level="1"><nlm:aff id="I11">University of Adelaide, Adelaide, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Scanavacca, Mauricio" sort="Scanavacca, Mauricio" uniqKey="Scanavacca M" first="Mauricio" last="Scanavacca">Mauricio Scanavacca</name><affiliation wicri:level="4"><nlm:aff id="I12">University of Sao Paulo, Sao Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>University of Sao Paulo, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Bernhardt, Alexandra A" sort="Bernhardt, Alexandra A" uniqKey="Bernhardt A" first="Alexandra A" last="Bernhardt">Alexandra A. Bernhardt</name><affiliation wicri:level="1"><nlm:aff id="I13">Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen</wicri:regionArea><wicri:noRegion>Ludwigshafen</wicri:noRegion><wicri:noRegion>Ludwigshafen</wicri:noRegion><wicri:noRegion>Ludwigshafen</wicri:noRegion></affiliation></author><author><name sortKey="Unniachan, Sreevalsa" sort="Unniachan, Sreevalsa" uniqKey="Unniachan S" first="Sreevalsa" last="Unniachan">Sreevalsa Unniachan</name><affiliation wicri:level="2"><nlm:aff id="I14">UMDNJ School of Public Health, Piscataway, NJ, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UMDNJ School of Public Health, Piscataway, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Phatak, Hemant M" sort="Phatak, Hemant M" uniqKey="Phatak H" first="Hemant M" last="Phatak">Hemant M. Phatak</name><affiliation wicri:level="2"><nlm:aff id="I2">Merck & Co., Inc, Whitehouse Station, Readington, NJ, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merck & Co., Inc, Whitehouse Station, Readington, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Gitt, Anselm K" sort="Gitt, Anselm K" uniqKey="Gitt A" first="Anselm K" last="Gitt">Anselm K. Gitt</name><affiliation wicri:level="1"><nlm:aff id="I13">Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen</wicri:regionArea><wicri:noRegion>Ludwigshafen</wicri:noRegion><wicri:noRegion>Ludwigshafen</wicri:noRegion><wicri:noRegion>Ludwigshafen</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Cardiovascular Disorders</title><idno type="eISSN">1471-2261</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Atrial fibrillation is a serious public health problem posing a considerable burden to not only patients, but the healthcare environment due to high rates of morbidity, mortality, and medical resource utilization. There are limited data on the variation in treatment practice patterns across different countries, healthcare settings and the associated health outcomes.</p></sec><sec><title>Methods/design</title><p>RHYTHM-AF was a prospective observational multinational study of management of recent onset atrial fibrillation patients considered for cardioversion designed to collect data on international treatment patterns and short term outcomes related to cardioversion. We present data collected in 10 countries between May 2010 and June 2011. Enrollment was ongoing in Italy and Brazil at the time of data analysis. Data were collected at the time of atrial fibrillation episode in all countries (Australia, Brazil, France, Germany, Italy, Netherlands, Poland, Spain, Sweden, United Kingdom), and cumulative follow-up data were collected at day 60 (±10) in all but Spain. Information on center characteristics, enrollment data, patient demographics, detail of atrial fibrillation episode, medical history, diagnostic procedures, acute treatment of atrial fibrillation, discharge information and the follow-up data on major events and rehospitalizations up to day 60 were collected.</p></sec><sec><title>Discussion</title><p>A total of 3940 patients were enrolled from 175 acute care centers. 70.5% of the centers were either academic (44%) or teaching (26%) hospitals with an overall median capacity of 510 beds. The sites were mostly specialized with anticoagulation clinics (65.9%), heart failure (75.1%) and hypertension clinics (60.1%) available. The RHYTHM-AF registry will provide insight into regional variability of antiarrhythmic and antithrombotic treatment of atrial fibrillation, the appropriateness of such treatments with respect to outcomes, and their cost-efficacy. Observations will help inform strategies to improve cardiovascular outcomes in patients with atrial fibrillation.</p></sec><sec><title>Trial registration</title><p>Clinical trials NCT01119716</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Heeringa, J" uniqKey="Heeringa J">J Heeringa</name></author><author><name sortKey="Van Der Kuip, Da" uniqKey="Van Der Kuip D">DA van der Kuip</name></author><author><name sortKey="Hofman, A" uniqKey="Hofman A">A Hofman</name></author><author><name sortKey="Kors, Ja" uniqKey="Kors J">JA Kors</name></author><author><name sortKey="Van Herpen, G" uniqKey="Van Herpen G">G van Herpen</name></author><author><name sortKey="Stricker, Bh" uniqKey="Stricker B">BH Stricker</name></author><author><name sortKey="Stijnen, T" uniqKey="Stijnen T">T Stijnen</name></author><author><name sortKey="Lip, Gy" uniqKey="Lip G">GY Lip</name></author><author><name sortKey="Witteman, Jc" uniqKey="Witteman J">JC 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Wit</name></author><author><name sortKey="Crijns, Hjgm" uniqKey="Crijns H">HJGM Crijns</name></author><author><name sortKey="Vrijhoef, Hjm" uniqKey="Vrijhoef H">HJM Vrijhoef</name></author><author><name sortKey="Prins, Mh" uniqKey="Prins M">MH Prins</name></author><author><name sortKey="Pisters, R" uniqKey="Pisters R">R Pisters</name></author><author><name sortKey="Pison, Lafg" uniqKey="Pison L">LAFG Pison</name></author><author><name sortKey="Blaauw, Y" uniqKey="Blaauw Y">Y Blaauw</name></author><author><name sortKey="Tieleman, Rg" uniqKey="Tieleman R">RG Tieleman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Brésil</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Communauté de Madrid</li><li>District de Cologne</li><li>Midlands de l'Ouest</li><li>New Jersey</li><li>Rhénanie-du-Nord-Westphalie</li><li>Svealand</li><li>État de São Paulo</li><li>Île-de-France</li></region><settlement><li>Birmingham</li><li>Bonn</li><li>Madrid</li><li>Paris</li><li>Stockholm</li><li>São Paulo</li></settlement><orgName><li>Université de Birmingham</li><li>Université de São Paulo</li></orgName></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Crijns, Harry Jgm" sort="Crijns, Harry Jgm" uniqKey="Crijns H" first="Harry Jgm" last="Crijns">Harry Jgm Crijns</name></noRegion></country><country name="États-Unis"><region name="New Jersey"><name sortKey="Bash, Lori D" sort="Bash, Lori D" uniqKey="Bash L" first="Lori D" last="Bash">Lori D. Bash</name></region><name sortKey="Phatak, Hemant M" sort="Phatak, Hemant M" uniqKey="Phatak H" first="Hemant M" last="Phatak">Hemant M. Phatak</name><name sortKey="Unniachan, Sreevalsa" sort="Unniachan, Sreevalsa" uniqKey="Unniachan S" first="Sreevalsa" last="Unniachan">Sreevalsa Unniachan</name></country><country name="France"><region name="Île-de-France"><name sortKey="Chazelle, Francois" sort="Chazelle, Francois" uniqKey="Chazelle F" first="François" last="Chazelle">François Chazelle</name></region><name sortKey="Le Heuzey, Jean Yves" sort="Le Heuzey, Jean Yves" uniqKey="Le Heuzey J" first="Jean-Yves" last="Le Heuzey">Jean-Yves Le Heuzey</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Lewalter, Thorsten" sort="Lewalter, Thorsten" uniqKey="Lewalter T" first="Thorsten" last="Lewalter">Thorsten Lewalter</name></region><name sortKey="Bernhardt, Alexandra A" sort="Bernhardt, Alexandra A" uniqKey="Bernhardt A" first="Alexandra A" last="Bernhardt">Alexandra A. Bernhardt</name><name sortKey="Gitt, Anselm K" sort="Gitt, Anselm K" uniqKey="Gitt A" first="Anselm K" last="Gitt">Anselm K. Gitt</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lip, Gregory Yh" sort="Lip, Gregory Yh" uniqKey="Lip G" first="Gregory Yh" last="Lip">Gregory Yh Lip</name></region></country><country name="Italie"><noRegion><name sortKey="Maggioni, Aldo P" sort="Maggioni, Aldo P" uniqKey="Maggioni A" first="Aldo P" last="Maggioni">Aldo P. Maggioni</name></noRegion></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Martin, Alfonso" sort="Martin, Alfonso" uniqKey="Martin A" first="Alfonso" last="Martín">Alfonso Martín</name></region></country><country name="Pologne"><noRegion><name sortKey="Ponikowski, Piotr" sort="Ponikowski, Piotr" uniqKey="Ponikowski P" first="Piotr" last="Ponikowski">Piotr Ponikowski</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Rosenqvist, M Rten" sort="Rosenqvist, M Rten" uniqKey="Rosenqvist M" first="M Rten" last="Rosenqvist">M Rten Rosenqvist</name></region></country><country name="Australie"><noRegion><name sortKey="Sanders, Prashanthan" sort="Sanders, Prashanthan" uniqKey="Sanders P" first="Prashanthan" last="Sanders">Prashanthan Sanders</name></noRegion></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Scanavacca, Mauricio" sort="Scanavacca, Mauricio" uniqKey="Scanavacca M" first="Mauricio" last="Scanavacca">Mauricio Scanavacca</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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